2017
Awad O, Panicker LM, Deranieh RM, Srikanth MP, Brown RA, Voit A, Peesay T, Park TS, Zambidis ET, Feldman RA. Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/ß-Catenin Downregulation. Stem Cell Reports. 2017 Dec 12;9(6):1853-1867.
Llosa, N, Cooke, KR; Chen, A, Gamper, CJ, Klein, O, Zambidis, E, Luber, B, Rosner, G, Siegel, Holuba, MJ, Robey, N, Hayashi, Jones, RJ, Fuchs, E, Holdhoff, M, Loeb, D, Symons, H. Reduced Intensity Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Solid Tumors in Pediatric and Young Adult Patients. Biol Blood Marrow Transplant. 2017 Dec;23(12):2127-2136.
Zimmerlin L, Park TS, Zambidis ET. Capturing Human Naïve Pluripotency in the Embryo and in the Dish. Stem Cells Dev, 2017, 16: 1141-1161.
Klein OR, Buddenbaum BS, Tucker N, Chen AR, Gamper CJ, Loeb D, Zambidis E, Llosa NJ, Huo JS, Robey N, Holuba MJ, Kasamon YL, McCurdy SR, Ambinder R, Bolanos-Meade J, Luznik L, Fuchs EJ, Jones RJ, Cooke KR, Symons HJ. Nonmyeloablative Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Pediatric and Young Adult Patients with High-Risk Hematologic Malignancies. Biol Blood Marrow Transplant 2017; 23(2):325-332.
2016
Zimmerlin L, Park TS, Huo JS, Verma K, Pather SR, Talbot CC Jr, Agarwal J, Steppan D, Zhang YW, Considine M, Guo H, Zhong X, Gutierrez C, Cope L, Canto-Soler MV, Friedman AD, Baylin SB, Zambidis ET. Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality. Development. 2016 Dec 1;143(23):4368-4380.
Nagaria PK, Robert C, Park TS, Huo JS, Zambidis ET, Rassool RF. High-fidelity reprogrammed human iPSCs have high efficacy of DNA repair and resemble hESCs in their MYC transcriptional signature. Stem Cells Int, Vol. 2016, http://dx.doi.org/10.1155/2016/3826249.
Salomonis, N, Dexheimer, PJ, Omberg, L, Schroll, R, Bush, S, Huo, JS, Schrimml, L, Sui, SH, Keddache, M, Mayhew, C, Witte, D, Wells, J, Daily, K, Hubler, S, Wang, Y, Zambidis, E, Margolin, A, Hide, W, Hatzopoulos, AK, Malik, P, Cancelas, JA, Aronow, B, and C Lutzko. Integrated genomic analysis of diverse induced pluripotent stem cells from the Progenitor Cell Biology Consortium. Stem Cell Rep. 2016 12;7(1): 110-125.
McMahan ZH, Cottrell TR, Wigley FM, Antiochos B, Zambidis ET, Park TS, Halushka MK, Gutierrez-Alamillo L, Cimbro R, Rosen A, Casciola-Rosen L. Autoantigens targeted in scleroderma patients with vascular disease are enriched in endothelial lineage cells. Arthritis Rheumatol. 2016 Oct;68(10):2540-9.
Klein OR, Chen AR, Gamper C, Loeb D, Zambidis E, Llosa N, Huo J, Dezern AE, Steppan D, Robey N, Holuba MJ, Cooke KR, Symons HJ. Alternative-Donor Hematopoietic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide for Nonmalignant Disorders. Biol Blood Marrow Transplant. 2016 May;22(5):895-901.
Zhu R, Millrod MA, Zambidis ET, Tung L. Variability of Action Potentials Within and Among Cardiac Cell Clusters Derived from Human Embryonic Stem Cells. Sci Rep. 2016 Jan 5;6:18544.
Jacoby E, Chen A, Loeb DM, Gamper CJ, Zambidis E, Llosa NJ, Huo J, Cooke KR, Jones R, Fuchs E, Luznik L, Symons HJ. Single-Agent Post-Transplantation Cyclophosphamide as Graft-versus-Host Disease Prophylaxis after Human Leukocyte Antigen-Matched Related Bone Marrow Transplantation for Pediatric and Young Adult Patients with Hematologic Malignancies. Biol Blood Marrow Transplant. 2016 Jan;22(1):112-8.
2015
Bazley FA, Liu CF, Yuan X, Hao H, All AH, De Los Angeles A, Zambidis ET, Gearhart JD, Kerr CL. Direct Reprogramming of Human Primordial Germ Cells into Induced Pluripotent Stem Cells: Efficient Generation of Genetically Engineered Germ Cells. Stem Cells Dev. 2015 Nov 15;24(22):2634-48.
Sgambato JA, Park TS, Miller D, Panicker LM, Sidransky E, Lun Y, Awad O, Bentzen SM, Zambidis ET, Feldman RA. Gaucher Disease-Induced Pluripotent Stem Cells Display Decreased Erythroid Potential and Aberrant Myelopoiesis. Stem Cells Transl Med. 2015 Aug;4(8):878-86.
2014
Mahairaki V, Ryu J, Peters A, Chang Q, Li T, Park TS, Burridge PW, Talbot CC Jr, Asnaghi L, Martin LJ, Zambidis ET, Koliatsos VE. Induced pluripotent stem cells from familial Alzheimer's disease patients differentiate into mature neurons with amyloidogenic properties. Stem Cells Dev. 2014 Dec 15;23(24):2996-3010.
Huo JS, Baylin SB, Zambidis ET. Cancer-like epigenetic derangements of human pluripotent stem cells and their impact on applications in regeneration and repair. Curr Opin Genet Dev. 2014 Oct;28:43-9.
Gorospe G, Zhu R, Millrod MA, Zambidis ET, Tung L, Vidal R. Automated grouping of action potentials of human embryonic stem cell-derived cardiomyocytes. IEEE Trans Biomed Eng. 2014 Sep;61(9):2389-95.
Agarwal, JR and Zambidis, ET. Role of an NFkB-STAT3 signaling axis in the induction and maintenance of the pluripotent state. Pluripotent Stem Cell Biology - Advances in Mechanisms, Methods and Models. Chapter 1. InTech, 2014.
Zhong X, Gutierrez C, Xue T, Hampton C, Vergara MN, Cao LH, Peters A, Park TS, Zambidis ET, Meyer JS, Gamm DM, Yau KW, Canto-Soler MV. Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs. Nat Commun. 2014 Jun 10;5:4047.
Panicker LM, Miller D, Awad O, Bose V, Lun Y, Park TS, Zambidis ET, Sgambato JA, Feldman RA. Gaucher iPSC-derived macrophages produce elevated levels of inflammatory mediators and serve as a new platform for therapeutic development. Stem Cells. 2014 Sep;32(9):2338-49.
Zimmerlin, L., Park, TS, Donnenberg, V.S., Zambidis, E. and A. D. Donnenberg. Pericytes: a ubiquitous source of adult tissue stem cells. In "Stem Cells in Aesthetic Procedures", edited by Melvin Shiffman, Springer, 2014 (Book Chapter).
Park TS, Donnenberg VS, Donnenberg AD, Zambidis ET, Zimmerlin L. Dynamic Interactions Between Cancer Stem Cells And Their Stromal Partners. Curr Pathobiol Rep. 2014 Mar 1;2(1):41-52.
Park TS, Bhutto I, Zimmerlin L, Huo JS, Nagaria P, Miller D, Rufaihah AJ, Talbot C, Aguilar J, Grebe R, Merges C, Reijo-Pera R, Feldman RA, Rassool F, Cooke J, Lutty G, Zambidis ET. Vascular progenitors from cord blood-derived induced pluripotent stem cells possess augmented capacity for regenerating ischemic retinal vasculature. Circulation. 2014 Jan 21;129(3):359-72.
2013
Zimmerlin L. Park, T.S., Zambidis E.T., Donnenberg, V.S. Donnenberg, A.D. Mesenchymal stem cell secretome and regenerative therapy after cancer.Biochimie, doi: 10.1016j.biochi.2013.05.010
Burridge P.W. and Zambidis E.T. Highly efficient directed differentiation of human induced pluripotent stem cells into cardiomyocytes. Pluripotent Stem Cells: Methods and Protocols, Chapter 12. Methods in Molecular Biology, vol. 997. Springer Science.
Rufaihah A. J., Huang N. F., Kim J., Herold J., Volz K.S., Park T.S., Lee J.C., Zambidis E.T., Reijio-Pera R., Cooke J.P.Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity. American Journal of Translational Research 2013;5(1):21-35
2012
Shah S.N., Kerr C., Cope L., Zambidis E., Liu C., Hillion J., Belton A., Huso D.L., Resar L.M. HMGA1 Reprograms Somatic Cells into Pluripotent Stem Cells by Inducing Stem Cell Transcriptional Networks. PLoS ONE 7(11): e48533.
Huo J.S., Zambidis E.T. Pivots of pluripotency: The roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells. Biochimica et Biophysica Acta (BBA) - General Subjects. Volume 1830, Issue 2, February 2013, Pages 2385–2394.
Panicker L.M., Miller D., Park T.S., Patel B., Azevedo J.L., Awad O., Masood M.A., Veenstra T.D., Goldin E., Stubblefield B.K., Tayebi N., Polumuri S.K., Vogel S.N., Sidransky E., Zambidis E.T., Feldman R.A.Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18054-9.
Park T.S., Huo J.S., Peters A., Talbot C.C. Jr., Verma K., Zimmerlin L., Kaplan I.M., Zambidis E.T. Growth Factor-Activated Stem Cell Circuits and Stromal Signals Cooperatively Accelerate Non-Integrated iPSC Reprogramming of Human Myeloid Progenitors. PLoS ONE 7(8): e42838.
Blazeski A., Zhu R., Hunter D.W., Weinberg S., Zambidis E.T., Tung L. Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility. Prog Biophys Mol Biol. 2012 Oct-Nov;110(2-3):166-77.
Blazeski A., Zhu R., Hunter D.W., Weinberg S., Zambidis E.T., Tung L. Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells. Prog Biophys Mol Biol. 2012 Oct-Nov;110(2-3):178-95.
Park T.S., Zimmerlin L., Zambidis E.T. Efficient and Simultaneous Generation of Hematopoietic and Vascular Progenitors from Human Induced Pluripotent Stem Cells.Cytometry A. 2013 Jan;83(1):114-26.
[Supporting Information]
Thompson, S.A., Burridge, P.W., Lipke, E.A., Shamblott, M., Zambidis, E.T., Tung, L. Engraftment of human embryonic stem cell derived cardiomyocytes improves 3 conduction in an arrhythmogenic in vitro model. J Mol Cell Cardiol. 2012 Jul;53(1):15-23.
Park T.S., Burridge P.W., Zambidis E.T. Generation of multipotent CD34+CD45+ hematopoietic progenitors from human induced pluripotent stem cells. Human Embryonic stem and Induced Pluripotent Stem Cells: Lineage-Specific Differentiation Protocols. Chapter 24, Springer Protocols Handbook 2012.
Peters A., Zambidis E.T. Generation of nonviral integration-free induced pluripotent stem cells from plucked human hair follicles. Human Embryonic stem and Induced Pluripotent Stem Cells: Lineage-Specific Differentiation Protocols Chapter 16, Springer Protocols Handbook 2012.
2009-2011
Burridge P.W., Thompson S., Millrod M.A., Weinberg S., Yuan X., Peters A., Mahairaki V. Koliatsos V.E., Tung L., Zambidis E.T.A Universal System for Highly Efficient Cardiac Differentiation of Human Induced Pluripotent Stem Cells That Eliminates Interline Variability.PLoS One. 2011 Apr 8;6(4):e18293.
[Burridge et al Supplemental Figures PLoS ONE]
Ohm JE, Mali P, Van Neste L, Berman DM, Liang L, Pandiyan K, Briggs KJ, Zhang W, Argani P, Simons B, Yu W, Matsui W, Van Criekinge W, Rassool FV, Zambidis E, Schuebel KE, Cope L, Yen J, Mohammad HP, Cheng L, Baylin SB. Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells. Cancer Res. 2010 Oct 1;70(19):7662-73.
Peters A., Burridge P.W., Pryzhkova M.V., Levine, M.A., Park T.S., Roxbury C., Yuan X., Peault B., Zambidis E.T. Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells. International Journal of Developmental Biology. Int J Dev Biol. 2010;54(6-7):965-90.
Pryzhkova M.V., Peters A., Zambidis E.T. Erythropoietic differentiation of a human embryonic stem cell line harbouring the sickle cell anaemia mutation.Reproductive Biomedicine online. 2010 August, 196-205.
Park T.S., Zambidis E.T. A role for the renin-angiotensin system in hematopoiesis. Haematologica. 2009 Jun;94(6):745-7.
Shah N., Zambidis E.T. False-photosensitivity and transient hemiparesis following high-dose intravenous and intrathecal methotrexate for treatment of acute lymphoblastic leukemia. Pediatr Blood Cancer. 2009 Jul;53(1):103-5.
Park T.S., Zambidis E.T., Lucitti J.L., Logar A., Keller B.B., Péault B. Human embryonic stem cell-derived hematoendothelial progenitors engraft chicken embryos. Exp Hematol. 2009 Jan;37(1):31-41.
2008 and earlier
Zambidis ET, Park TS, Yu W, Tam A, Levine M, Yuan X, Pryzhkova M, Péault B. Expression of angiotensin-converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells. Blood. 2008 Nov 1;112(9):3601-14.
Zambidis ET, Sinka L, Tavian M, Jokubaitis V, Park TS, Simmons P, Péault B. Emergence of human angiohematopoietic cells in normal development and from cultured embryonic stem cells. Ann N Y Acad Sci. 2007 Jun;1106:223-32.
Zambidis ET, Oberlin E, Tavian M, Péault B. Blood-forming endothelium in human ontogeny: lessons from in utero development and embryonic stem cell culture. Trends Cardiovasc Med. 2006 Apr;16(3):95-101.
Zambidis ET, Peault B, Park TS, Bunz F, Civin CI. Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development. Blood. 2005 Aug 1;106(3):860-70.
Agarwal RK, Kang Y, Zambidis E, Scott DW, Chan CC, Caspi RR. Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis. J Clin Invest. 2000 Jul;106(2):245-52.
Zambidis ET, Kurup A, Scott DW. Genetically transferred central and peripheral immune tolerance via retroviral-mediated expression of immunogenic epitopes in hematopoietic progenitors or peripheral B lymphocytes. Mol Med. 1997 Mar;3(3):212-24.
Zambidis ET, Barth RK, Scott DW. Both resting and activated B lymphocytes expressing engineered peptide-Ig molecules serve as highly efficient tolerogenic vehicles in immunocompetent adult recipients. J Immunol. 1997 Mar 1;158(5):2174-82.
Zambidis ET, Scott DW. Epitope-specific tolerance induction with an engineered immunoglobulin.Proc Natl Acad Sci U S A. 1996 May 14;93(10):5019-24.
